Surgical treatments for intracerebral hematomas include craniotomy, stereotactic hematoma removal, and endoscopic hematoma removal. The 2021 Japanese Stroke Guideline recommends stereotactic hematoma removal for putaminal hemorrhage when certain criteria are met, including specific hematoma volume, evidence of hematoma compression, and relevant neurological findings. Conventionally, a frame is affixed to the patient's head, the hematoma coordinates are measured in the computed tomography (CT) room, and stereotactic hematoma removal is performed in the operating room. In this case report, in addition to coordinate measurement in the CT room, cone-beam computed tomography (cone-beam CT) was used in a hybrid operating room. The patient was a 59-year-old male with a history of hypertension. He was admitted to our hospital with left hemiplegia upon waking and was diagnosed with right putaminal hemorrhage. Stereotactic hematoma removal was subsequently performed. There was no significant difference between hematoma coordinates measured by conventional CT and those obtained by cone-beam CT. The procedure did not require moving the patient between the CT and operating rooms, and intracranial evaluation was possible immediately after surgery on the operating table. These findings suggest that stereotactic hematoma removal based on coordinate measurements using cone-beam CT may be a useful approach.